The U.S. national team coach believes his side is capable of achieving the upset, saying the Americans "have absolutely no fear at all."
The USA has beaten the odds in the tournament so far, coming through Group G ahead of Ghana and Portugal after a 2-1 win and 2-2 draw against the two sides, respectively.
Klinsmann was branded "un-American" by some in the U.S. media before the World Cup for saying that winning the tournament was "just not realistic" for his side. But he has now talked up his team's chances against Marc Wilmots' outfit.
"We have enough confidence now going into this game — a very special one, a knockout game — to say we are able to beat them," the 49-year-old said during a news conference.
"Belgium are one of the secret favorites in this World Cup because of the players, individual players, that they have," he added. "We have absolutely no fear at all. We feel like we are in a position now to challenge. We believe we have built a foundation in our team that we are able to beat them.
"I was definitely not as happy as with the first two games with the performance they had against Germany. Now, going into knockout games, everyone has to call up his 100 percent for the team. I believe that in our team so far, nobody can claim that he reached his 100 percent yet. This is a very important message to the players, is that now [they must] prove it."