The African nation has eliminated the Americans from the past two World Cups and will attempt to make it a hat trick of victories on Monday night.
Tim Howard says the U.S. national team will not think about previous failures against Ghana when it faces the African nation Monday night.
Ghana beat the USA in the group stage at the 2006 tournament, before emerging victorious again in the second round four years later.
The two sides have been paired yet again in Group G this time around, along with Portugal and Germany, but Howard is confident the previous meetings between the nations will have little impact.
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"Not a word's been spoken (about the previous games)," the Everton goalkeeper said. "We've said that all along. That was four years ago. It's ancient history, really, in the way football is looked at. This is a different team, with a different mindset."
Howard did acknowledge, however, that Ghana would pose similar threats to last time: "I think they are very similar (to 2010). They are strong individually. Obviously, we know how physical they are so we are going to try to match that. I've said it before, very rarely do we get outmatched physically but this is a team that has the possibility of doing that.
"We'll make sure that doesn't happen and then just be kind of clever with our positioning and making sure that they don't hit us in transition."