USA teammates Fabian Johnson and Danny Williams both netted in a 3-1 win over Hannover.
Hannover actually took the lead thanks to an own goal 26 minutes in, but Johnson answered a minute later to pull his team level.
Sejad Salihovic scored late on to give Hoffenheim the lead, with Williams netting an insurance goal in stoppage time.
The win is a boost to a Hoffenheim side that is off to a very poor start in the league and was looking for its first points coming into the day. The match was also Hannover's first loss of the season.
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