An injury to star striker Emmanuel "Tito" Villa could derail the ambitions of CCL debutant Tigres.
|Tigres UANL (4-4-2): Palos; Jimenez; Ayala, Juninho, J.E. Torres; Salcido, Alvarez, Lobos, J.F. Torres; Garcia, Danilinho.
|Seattle Sounders (4-4-2): Gspurning; Scott, Yedlin, Hurtado, Gonzalez; Martinez, Rose, Evans, Zakuani; Rosales, Johnson.
- Tigres striker Emmanuel "Tito" Villa leads the Liga MX Clausura with eight goals in as many matches, but is out for four to five weeks with a calf strain.
- Seattle head coach Sigi Schmid is one of two American head coaches to have tasted regional supremacy, having led the LA Galaxy to the 2000 CONCACAF Champions Cup.
- This is Seattle's third consecutive year in the CCL, a run that will not continue next cycle as the Sounders failed to qualify. Seattle has never made it beyond the CCL quarterfinal stage.
- This is Tigres' first campaign in the CCL, and the Nueva Leon side's first crack at the knockout round.
- On Seattle's last trip to the CCL knockout stages last year, it defeated Santos Laguna 2-1 in the home leg only to get turned over 6-1 on the road.