Andres Iniesta has been withdrawn from Spain's squad for the matches against France and Macedonia after suffering a knee injury.
The Barcelona midfielder missed Sunday's La Liga match at Villarreal, with club coach Luis Enrique confirming that the 30-year-old was experiencing "some knee discomfort."
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And the experienced playmaker has now been ruled out of Thursday's friendly in Paris and the visit of Macedonia for a Euro 2016 qualifier next Monday, with Barcelona confirming on its official website that the player has withdrawn from the camp.
Vicente del Bosque has not called up a replacement, so he will pick from a 22-man squad for the two games.
Iniesta earned his 100th cap in the 3-0 victory over Australia in Spain's final World Cup group match in Brazil. He is eighth in the list of all-time appearances for Spain.