Robinho returns to the Brazilian squad for the first time since 2011 while young Paris Saint-Germain star Marquinhos will be hoping to make his debut.
Luiz Felipe Scolari's men take on the Central American outfit in Miami on Saturday as they step up preparations for the first World Cup to be held in Brazil in 64 years.
Robinho returns to the squad for the first time since 2011, while Marquinhos has received his first international call-up and is hoping to make his Selecao debut.
Scolari has an array of attacking talent to choose from despite being without injured Fluminense striker Fred, including Barcelona attacker Neymar and Zenit St. Petersburg forward Hulk.
A number of players will be looking to stake their claim for a spot in the World Cup, with Paris Saint-Germain defender Maxwell among them. The 32-year-old looks set to fill in at left back in the absence of injured Real Madrid defender Marcelo (knee).
Thiago Silva has been training alone this week but hopes to be involved, as does Dani Alves, who limped out of training with a knock yesterday.
Brazil will be considered the favorite for this clash, having lost just one of the five meetings between the two countries. But Scolari's men will need to be wary of a side that beat Mexico to third place to seal automatic qualification for the World Cup in the final stage of CONCACAF qualifying.
Luis Fernando Suarez's men lost just three of their 10 games in the last round of qualifying, and in Jerry Bengtson and Carlo Costly they boast two talented strikers. The duo scored 16 goals between them during qualification, but may have difficulty finding the net against a Brazil defense that has been stout of late.
Scolari's charges conceded just three goals in the Confederations Cup in June and have seen their back line breached only twice in their last five outings.