The Manchester United striker sustained a gash to his head in training and his Scottish boss has ruled out any involvement in the Three Lions' upcoming World Cup qualifiers.
The England international's future has been engulfed in uncertainty since he asked to leave Old Trafford at the end of last season, but he had worked his way back into the reckoning to star in United's draw against potential suitor Chelsea.
However, Rooney missed United's clash with Liverpool with the head injury sustained in training, and is highly unlikely to play any part in England's upcoming matches against Moldova and Ukraine.
"Wayne Rooney has got a cut down his forehead, it was completely accidental," Moyes told Sky Sports.
"It will keep him out for a few weeks. I would think he's got no chance of playing for England."
Only four players have scored more goals in an England shirt than Rooney, and his absence will be a big blow to Roy Hodgson ahead of a tricky doubleheader of World Cup qualifiers.