The Chilean has brought to an end a near 12-month absence from the game as he takes charge of the ninth club of his coaching career
Marseille has announced the appointment of Marcelo Bielsa as head coach on a two-year deal.
Jose Anigo has been the club's interim boss since the December departure of Elie Baup, but OM has opted not to hand the 53-year-old the position on a permanent basis.
Bielsa has earned a reputation as an attacking and innovative coach during a 24-year managerial career that has included spells in charge of Argentina, Chile and Athletic Bilbao in recent years.
The 58-year-old departed Bilbao at the end of his contract in June 2013 and turned down the chance to manage Paraguay before ending his near 12-month absence from the game on Friday.
Marseille's president Labrune Vincent said: "I can tell you that our lawyers and those of Marcelo Bielsa have reached a legal and contractual agreement which makes Marcelo Bielsa the next coach of Olympique de Marseille for the next two seasons."
OM is currently sixth in Ligue 1 having finished runner-up to reigning champion Paris Saint-Germain last term. The club last lifted the league title in 2010.