Laurent Blanc's side was beaten in the Champions League by Benfica on Tuesday - just the second loss this season - but will be expected to return to winning ways this weekend.
Laurent Blanc's men suffered only their second defeat of the season in all competitions on Tuesday as they were beaten 2-1 by Benfica in an ultimately meaningless Champions League clash.
Blanc rotated much of his squad for that game at Estadio da Luz, with superstar duo Zlatan Ibrahimovic and Thiago Silva among those left out completely.
Those players should all return for the trip to the Stade de la Route de Lorient, a venue where PSG has won just once in the last 11 visits.
The defending champion has no new injury worries for the trip to Brittany and the capital club will also be boosted by the return of midfielder Marco Verratti and defender Gregory van der Wiel, who were both suspended for the defeat to Benfica.
PSG may have a dismal record on its travels at Rennes, but should be confident of cementing its grip on top spot against a side on a dreadful run of form.
Rennes made a strong start to life under former Real Sociedad coach Philippe Montainer, losing just one of its first seven league games.
However, the club has struggled to maintain that momentum and sits 13th in Ligue 1 having earned only one win since October.
Last season's Coupe de la Ligue finalist was beaten 2-0 by PSG in the corresponding fixture in 2012-13, with Jeremy Menez and Ibrahimovic the difference between the sides.
The home side is without one of its key first-team players as the club looks to avenge that defeat, with defender Sylvain Armand - who left PSG to join Rennes in the close season - suspended after being sent off in the 2-0 loss to local rival Lorient last weekend.
Wingers Romain Alessandrini and Foued Kadir are both set to return for Rennes and defenders John Boye and Jean-Armel Kana-Biyik, who missed the trip to Lorient - should also be fit to play.