The Colombian suffered an ankle injury and had to be replaced by Emmanuel Riviere, who ended up netting the winner to propel Claudio Ranieri's men to the top of the standings.
Monaco moved back to the top of Ligue 1 as it ended Marseille's unbeaten record with a 2-1 win at the Stade Velodrome on Sunday, but the club paid a price for its win as star striker Radamel Falcao suffered an ankle injury that forced him off in the second half..
Monaco is still yet to taste defeat since earning promotion from Ligue 2 last season but had to come from behind to seal the three points. Marseille went in front just a minute before halftime as Lucas Mendes headed in Mathieu Valbuena's corner.
That advantage did not last long, though, as Falcao equalized in the 47th minute with his third goal of the season prior to suffering his injury. His replacement, Emmanuel Riviere, came on in the 73rd minute and scored the winner with his fifth of the campaign.
Riviere, who was signed from Toulouse in January, slotted home after latching on to a superb through ball from Joao Moutinho in the 80th minute to secure all three points. The severity of Falcao's injury is yet to be determined, but the knock comes at an inopportune time for his native country, Colombia. Los Cafeteros face Ecuador and Uruguay in a pair of crucial World Cup qualifying matches on the upcoming international fixture dates.