The 34 year old forward displaces the Bayern Munich striker up front, with both Andre Schurrle and Marco Reus handed starting berths in the Euro 2012 quarterfinal.
Mario Gomez has been dropped in favor of Miroslav Klose, with the Lazio man earning his 120th cap against Greece at the PGE Arena in Gdansk.
The 52-year-old has also sprung a surprise by naming Marco Reus and Andre Schurrle in favor of tournament stalwarts Lukas Podolski and Thomas Muller.
Right back Jerome Boateng returns from suspension, and replaces Lars Bender in defense as Germany seek a place in the semifinal this evening.
Greece coach Fernando Santos has drafted in Panathinaikos midfielder Sotiris Ninis to replace Theofanis Gekas in a three-man attack against Germany.
Grigoris Makis replaces suspended captain and goalscorer against Russia Giorgos Karagounis with the Ethniki searching for their very first win against die Mannschaft.
Left back Giorgos Tzavellas was a doubt before kickoff with a thigh injury, but has passed a fitness test to feature in the quarter-final. His replacement Jose Holebas is suspended.
Germany (4-2-3-1): Neuer; Boateng, Hummels, Badstuber, Lahm; Khedira, Schweinsteiger; Reus, Ozil, Schurrle; Klose.
Greece (4-3-3): Sifakis; Torossidis, Sokratis, Papadopoulos, Tzavellas; Makos, Maniatis, Katsouranis; Ninis, Salpingidis, Samaras.