The 24-year-old thinks that Croatia can cause an upset against Del Bosque's men, while Nikica Jelavic has insisted that his side will play to winIvan Rakitic believes that Croatia can disrupt Spain's free-flowing football by following Italy's example and attacking La Roja's midfield.
Slaven Bilic's side goes into its final Group C game against the world and European champions in second place, level on points with Vicente del Bosque's men, knowing that a win would see them progress as group winners.
And the Sevilla midfielder believes that Croatia's opponents are beatable, and suggested that his side can take heart from the way in which Italy attacked the midfield, forcing the World Champions to make mistakes.
"It is possible to attack this Spain, after all Switzerland beat them in the  World Cup." The 24-year-old told reporters. "They are humans, have their flaws, make mistakes, and we have to exploit those mistakes.
"When the chance comes up, we must grab it. We proved our quality, now we decide on our own destiny, and of course we have a great confidence.
"I guess we are all aware of the fact that Spain will have a possession. We have to be aggressive, don't allow them to cut into attacking third easily. The Italians showed us how to oppose Spain - the midfield must be aggressive."
Rakitic will come up against two of the best midfielders in the world in Andres Iniesta and Xavi on Monday, the 24-year-old could not chose between the two, adding that their whole squad is of the highest quality.
"Oh, what a choice. I guess that is picking the better one out of two best players in the world. I would prefer if we could stop them both equally, that would be perfect," he continued.
"But, they have 23 fantastic players, two teams that could win this tournament, and who ever plays he'll be dangerous."
The Spanish side has dominated major tournaments over the last four years, winning the World Cup in South Africa after the last European Championship in Austria and Switzerland, all the while playing an attractive 'tiki-taka' brand of football.
Everton striker Nikica Jelavic has been in decent form for his country so far at Euro 2012, scoring in its opening 3-1 win over Republic of Ireland.
And the forward is looking forward to the challenge of facing big names such as Sergio Ramos and Gerard Pique, but admitted he may not see much of the ball.
"They are top players, and I'm glad that I'm having a chance to confront them, to see how good I am. I hope that two touches will be enough to score," the 26-year-old said.
"It is going to be difficult match, probably with not that many chances, and we have to use every single one that pops up.
"We know all about them, they know all about us, there are no secrets. If you ask me, Spain and Germany are the favorites to win this tournament, together with Croatia. We are going to play for a win."
Croatia and Spain kick off at 2:45 p.m. ET on Monday.