The retired custodian is confident that the Oranje will do well in their Euro group and believes that they will be able to beat La Roja if they meet up during the tournament
The 41-year-old, who retired from football last year, reckons that La Roja are rightly favored to retain their European crown, but insists that the Oranje can cause Vicente del Bosque's side all sorts of problems if they are able to keep the same level shown in recent matches.
"For the Euro, the favourites are Spain," Van der Sar told Goal.com. "They have a very strong team with a great generation of young players and were amazing in the last World Cup. Another great rival will be Germany.
"Netherlands had a very good game the other day. I hope that they will take revenge for the defeat in the final against Spain two years ago."
The Oranje have been drawn with Germany, Portugal and Denmark, but Van der Sar says that history speaks in favor of his country's national team.
"Netherlands have a very difficult group," he explains. "But the last few times we were in a 'group of death' like this, I think we did great, and I hope the same will happen this time."
Van der Sar then heaped praise on Real Madrid goalkeeper Iker Casillas, who recently surpassed his international tally to become the fourth-highest-capped custodian in football.
"What can I say about Casillas? He is 31 and has won everything," he added. "We all started playing senior football at the age of 23 and I think he started at 17 or 18 in Real Madrid's first team.
"His form throughout the years has been magnificent all this time, for Real Madrid and Spain. I do not know him personally, but I have read his interviews and I have never heard anything bad about him. He is a great captain for Madrid and Spain."
The Dutchman also commented on the difficult start that David de Gea had at Manchester United as the former Atletico Madrid shot-stopper was often criticised by fans and the press.
"Manchester United signed David de Gea to be their keeper for many years," Van der Sar noted. "He is still very young. This year has been a difficult challenge for him. You cannot compare the Premier League with La Liga, they are completely different.
"He had some difficult matches in which he made some mistakes, but after this period he began to show some good saves and quick reactions. Without those last minutes in City's final Premier League game, he would have won his first title with United."
Van der Sar went on to offer his backing to Sir Alex Ferguson after United failed to secure a single title this season.
"This was not a good campaign for Manchester United," he explained. "They were very close to winning the Premier League, but unfortunately they were not successful. It is hard to say what they need. Chelsea are very strong now, Arsenal are maturing, and City will continue to demonstrate all their power.
"It will be difficult for United, but I trust Sir Alex."
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