The former Argentine physician has voiced his concerns over the forward's physical state in light of recent injuries.
The Barcelona star has been plagued by physical problems in the past few months, and Signorini feels the attacker needs a prolonged holiday in order to leave his fitness issues behind him.
"Messi plays over 100 games a year with Barcelona and Argentina. That brings the risk with it that he will not be in peak condition at the 2014 World Cup," Signorini told Telam. "Messi had not had any injuries for three years or so, but when he picked up an injury toward the end of the season, he was played almost right away again.
"He then got injured again and is now playing for the national team. What he needs is a lengthy holiday with his wife and son. It's impossible to play over 100 games in modern football and still be in top condition."
Messi made 50 official appearances for Barcelona in all competitions in 2012-13.