The three-time World Cup winner has reacted angrily to the suggestion that the teenager has to leave his homeland if he is to fully develop as a player
Neymar is considered one of the most exciting young talents in the game and he recently committed his future to Santos until after the 2014 World Cup.
Menezes recently claimed that the player would be then well advised to try his luck in one of Europe's top leagues but Pele can see no reason why the teenager needs to leave his homeland in order to prove himself.
"I think that Mano does not like Santos," the three-time World Cup winner told Marca Brasil. "I am totally against the sale of Neymar.
"I played my whole life here and Neymar has a chance to continue playing for Santos; to continue winning and doing the work he has been doing with the the national team.
"He will still be Neymar, the best in the world."
Pele then used the example of former Santos starlet Robinho to underline his point that moving abroad is not always the best option.
"You have to be careful," the Brazil legend argued. "Robinho was fine when he left in 2005 for Real Madrid and it took him almost a year to adapt and he was a reserve [until then].
"He [Neymar] almost went to England. I also went and got to speak with him and turn him against it, because he can not play in England or Germany.
"If you go abroad, you have to go where football is more technical, like in Spain and France, but I do not want him to leave."
Neymar, at just 19, has already been capped 16 times by the Selecao.