The Three Lions' boss is worried the Arsenal man could have suffered a serious injury after impressing during the 2-2 draw with Ecuador in Miami
The Arsenal winger impressed during the Three Lions' 2-2 draw with Ecuador in Miami, but was forced from the field after 63 minutes following a challenge from Carlos Gruezo.
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Oxlade-Chamberlain's ankle was caught by the South American midfielder, but it was the way in which he landed on his knee that caused his withdrawal, and Hodgson admitted it could be a serious injury.
Speaking to the BBC, the former Liverpool manager said: "We have our fears there might be some ligament damage."
Oxlade-Chamberlain, 20, has only just recovered from a groin injury that saw him miss the end of Arsenal's Premier League season. He will be sent for a scan prior to England's final pre-World Cup friendly against Honduras on Saturday.