The former Barcelona coach often rests high-profile names such as Dutchman due to the Bavarians' busy schedule.
However, Guardiola's spouse believes that her husband would be better of sticking with a winning lineup.
"My wife Cristina often complains about my tactics," the former Spain international told reporters. "She keeps on telling me that I should stick with the players who won the last match.
"Exlaining her my rotation system is much harder than telling Arjen Robben that he will have to settle for a spot on the bench ..."
Guardiola is widely regarded as one of the top coaches in the game but he has admitted that he was not sure he would enjoy such a successful beginning to his Bayern career.
"There's not a single coach out there who can guarantee success at the start of the season," he pointed out. "There is no magic formula to win.
"Football would be like a shopping mall if that was the case. Everybody would come in and just pick the part he needs. But there would be no challenge in that."
Guardiola replaced Jupp Heynckes as Bayern boss last summer and the Bavarians are currently perfectly place to successfully defend their Bundelisga, DFB-Pokal and Champions League titles.