The 25-year-old was substituted at halftime of Mexico's goalless draw with Nigeria after a collision with goalkeeper Vincent Enyeama, complaining of pain in his right knee.
Manchester United striker Chicharito is set to undergo tests on a knee injury picked up in Mexico's clash with Nigeria on Wednesday.
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The 25-year-old was involved in a collision with goalkeeper Vincent Enyeama during the goalless draw, and was replaced by Alan Pulido at halftime.
After the match, Chicharito confirmed he was suffering pain in his right knee.
"It really hurts," he is quoted as saying by Univision. "The goalkeeper fell on top of me, I'll wait for the tests."
However, Mexico team doctor Jose Guadalupe Vazquez moved to cool concerns of a serious problem, telling ESPN: "It is a bruise, but we have to rule out any ligament strain.
"He only has pain and he doesn’t have a history of knee instability. The bruise is in the middle part of the knee. We will have to wait to see whether it is a strain."
Chicharito could now miss Manchester United's trip to West Brom in the Premier League on Saturday.