Vlad Chiriches has been forced to withdraw from Romania's squad for its two-legged World Cup qualifying playoff with Greece.
The Tottenham center back suffered a blow to the face in his club's 1-0 Premier League defeat to Newcastle on Sunday.
When asked about Chiriches' injury after the game, Spurs boss Andre Villas-Boas told the press: "I think he broke his nose."
The Romanian Football Federation confirmed in a statement Monday that the former Steaua Bucharest man, who has 22 caps, would not be fit to feature in either match against Greece.
Dinamo Bucharest's Dragos Grigore has been named as a replacement for the 23-year-old defender.
Romania plays the away leg of its playoff with Greece in Piraeus on Friday, with the return match taking place in Bucharest four days later.