With a 3-0 defeat to West Ham behind them, Spurs will look to carry over the winning ways many players experienced for their national teams.
The north London side fell to a shock 3-0 defeat to its local rival before the international break to drop it to sixth in the standings. But Holtby feels the time away will have helped boost the players' morale - with many of Spurs' stars recording wins for their respective nations - ahead of the trip to Aston Villa on Sunday.
"It was vital for everyone, especially after that Russia trip [to Anzhi Makhachkala in the Europa League], to have a break, and to go with the national teams to get some good experience like the Belgium and England lads did," the 23-year-old told the club's official website. "They achieved a ticket for the World Cup, and a lot of other players won with their countries, so for everyone the confidence is very important."
Spurs' last visit to Villa Park saw them pick up a 4-0 win, and Holtby is hoping to repeat the September performance that earned them a place in the next round of the Capital One Cup.
"I'm definitely looking forward to going in that dressing room again because I’ve got good memories of it," he said. "I think we’re up for it. Especially everyone who played against West Ham is definitely looking to come back from the result we had. We must keep it out of our minds, and try to get a win. We've won twice at Aston Villa now, twice 4-0. But they will be up for it as well."