The striker, who picked up an injury in Manchester United's trip to Shakhtar, will be unlikely to feature for the Brazil-bound Oranje in their final two games.
Having picked up the knock during the Red Devils' 1-1 draw against Shakhtar Donetsk in the Champions League, the striker played through the pain in United's 2-1 victory over Sunderland on Saturday.
However, the 30-year-old remains a doubt for the Netherlands' final two qualifiers against Hungary in Amsterdam and Turkey in Istanbul as Louis van Gaal's side looks to remain unbeaten in Group D.
"I got an enormous stamp on my toe and I really thought it had been broken but, luckily, a scan showed it was not," van Persie told reporters. "I played on Sunday [in the 2-1 win at Sunderland] but the injury has not got better."
Van Gaal's men have already secured qualification through to next year's finals in Brazil but van Persie will be keen to add to his tally of 38 goals for his national side and surpass Patrick Kluivert's record haul of 40.