The Chelsea left back will miss the upcoming doubleheader against Montenegro and Poland due to a long-standing rib injury, with Kieran Gibbs called up as his replacement.
The Chelsea left back was named in Roy Hodgson's initial 23-man squad for the doubleheader, but he suffered a rib injury in the club's 3-1 win over Norwich City on Sunday. Arsenal defender Kieran Gibbs has been called up as his replacement.
Cole, who earned his 105th cap for England against Ukraine in September, underwent a scan on Monday morning and is now set for a yet-to-be-confirmed amount of time on the sidelines.
Chelsea manager, Jose Mourinho, said of the injury on Sunday: "He is having this little problem for quite a while. He was feeling it hard in the ribs, but I didn't [substitute] him because of that."
England currently tops Group H by just one point following the 1-1 draw with Ukraine, and needs to win both of its final group games to be sure of securing a place in next summer's World Cup.
The Three Lions host Montenegro on Friday before Poland arrives at Wembley on Oct. 15.