In the game of the weekend, Chelsea takes on Everton at Goodison Park in Saturday's late kickoff, while reigning champion Manchester United welcomes newly promoted Crystal Palace to Old Trafford.
Arsenal, fresh from the record signing of Mesut Ozil, travels north to face Sunderland, as table-topping Liverpool looks to maintain its perfect record with an away trip to Swansea on Monday, as Brendan Rodgers faces his old side.
This week, former Liverpool, Manchester City and Newcastle midfielder Didi Hamann gives us his predictions, but let's see if can beat former Chelsea captain Dennis Wise's attempt.
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Last time out, Wise scored four out of nine, with a perfect prediction for Norwich's 1-0 victory over Southampton. Not bad, but his former teammate Gus Poyet still leads the way. Can Hamann do any better?
Didi has had his say, and now you can too! Leave your predictions in the comments below and vote on how you think he will fare.