The goalkeeper is eager to make amends for his side's Champions League final defeat to the Blues, while explaining the differences between Pep Guardiola and Jupp Heynckes.
Though the Bavarians lifted the Champions League trophy by beating Borussia Dortmund in May, they were beaten on penalties by the Blues in the 2012 final, and the goalkeeper admits that there is still a score to settle with the Premier League side.
"It's a unique chance for us players to win this trophy," Neuer told UEFA.com. "It's a final and a match against the Europa League winners, and that's Chelsea. We still have something to clear with them, and take revenge, so hopefully we can win in Prague."
Neuer then gave insight into the pressure that Bayern was under ahead of last season's Champions League final, noting that the prospect of defeat at Wembley was unthinkable.
"[Winning the Champions League] was very important," the Germany international remarked. "We would have had a very difficult time if we hadn't done it. Last season we were very motivated, we wanted to finally achieve a lot of success and managed to win the treble, but we could have never lost the final against Dortmund."
Pep Guardiola has since taken over from Jupp Heynckes as Bayern boss and guided the treble-winners to wins in all three of their opening Bundesliga matches, with the latest a 2-0 victory over Nurnberg, and Neuer explained the differences between the former Barcelona boss and Heynckes, having gotten to know the Spaniard in recent months.
"He's certainly a totally different person to Heynckes," Neuer said. "Jupp had a lot of experience from coaching many big clubs in Europe and he had a good feeling for different situations.
"We've not played under Pep for that long, but he's clearly an advocate of attractive football, just like Jupp."