Europe's governing body claims clubs are benefiting from improved financial stability despite the likes of Monaco and Real Madrid splashing out this summer
Teams like Monaco have spent lavish sums over the past two seasons, with the Ligue 1 newcomer investing upwards of 130 million euros this summer alone on new signings - although its absence from European competition allows the team certain leeway.
Meanwhile, Arsenal boss Arsene Wenger claimed Real Madrid's proposed 115 million-euro bid for Gareth Bale "made a joke" of UEFA's regulations, but Infantino has made it clear that such a sum is easily possible for a club which generates sufficient income.
He told the Press Association: "People see these signings and ask how it can happen with Financial Fair Play but it's possible - if you generate 100 million euros you can spend 100 million euros.
"The other thing which must be taken into account is that a club may have an agreement to pay that over five years, so the cost is 20 million euros for the season.
"The problem comes is if a club doesn't generate 100 million euros but spends it - then there will be disciplinary consequences."
The likes of Malaga and Panathinaikos have been hit with sanctions having failed to adhere to FFP guidelines, and, while Infantino acknowledges that banning clubs from competitions is tough for some to take, he insists UEFA's efforts are paying dividends on the whole.
"No one likes to punish clubs but we will do it," he continued. "In the last five years we have excluded 41 clubs from European competition and eight this season have not been admitted.
"It is quite positive. It shows Financial Fair Play is working and that it's happening right now. Overall losses in European club football are down for the first time, and by several hundreds of millions [of euros]."