The 29-year-old Roma veteran has been the subject of interest from Chelsea, and the Italy head coach believes a summer switch would benefit his progress as a player.
The 29-year-old De Rossi has spent his entire career with the Giallorossi, but strong rumors of interest from Jose Mourinho at Chelsea could sway De Rossi to leave the club he adores. Prandelli says a move elsewhere would be a good thing for the midfielder's development.
"Maybe leaving Roma would be a defeat on a personal level for Daniele De Rossi, but professionally I believe it would be a good thing," Prandelli told RAI.
De Rossi has made more than 400 appearances for Roma, scoring 47 goals since his debut in 2001. He has won two Coppa Italias in his time at the club, as well as the 2006 World Cup with Italy.