The Barcelona assistant doubts the Portuguese's departure will weaken the Blancos and revealed that Tito Vilanova has once more returned from his cancer treatment in New York
The Portuguese was long rumored to be leaving the Santiago Bernabeu and it was finally confirmed this week, though the Blaugrana assistant was reluctant to read too much into the exit.
Roura said: "It's not up to me to comment on [Mourinho leaving]. Madrid will always be a difficult opponent."
Roura also revealed that Tito Vilanova has returned from further cancer treatment in New York and reported that the head coach is looking healthy.
He added: "Tito has arrived back from New York very cheerful. He looks happy - the tests went well and he looks good."
Barca faces city rival Espanyol in the penultimate Liga game of the season and Roura said it is up to its opposition if it wants to give a guard of honor, while revealing Carles Puyol will be rested though Dani Alves could feature.
"[Espanyol] are free to do what they want. We can't say anything, Espanyol can decide," he continued.
"Alves trained well, we'll see tomorrow if he can play. We will focus on Puyol returning next season as we want him to be back totally recovered."
Barca kicks off against its local rival on Sunday as it pursues the 100-point mark - something it has never reached before and requires two wins out of two to achieve.