Wolves striker Kevin Doyle has been called up to replace the Ireland captain after he picked up a calf injury that could keep him out of CCL action for the Galaxy as well.
"The Football Association of Ireland today confirmed that Robbie Keane has been ruled out of Tuesday's FIFA World Cup qualifier against Austria in Aviva Stadium," a statement from the Irish FA read. "A scan this morning confirmed that Robbie is suffering from calf strain after Friday's game against Sweden. Wolves striker Kevin Doyle has been called up in place of Keane.
"The manager has spoken to Kevin, and he will link up with the squad in time for training in Malahide tomorrow morning."
The news will be a big blow to an Irish side that is currently fourth in Group C with seven points from four matches considering that the opponent is only ahead of Trapattoni's side on goal difference.
Though the timetable for the injury is unknown the news will also be unwelcome for the Galaxy, with the team set to face off with Toronto in league play next weekend before taking on Monterrey in the CONCACAF Champions League semifinal first leg on April 3.
The Galaxy are also waiting on the return to action of star midfielder Landon Donovan, who has been on an extended vacation since the end of last season.