The Turkish official controversially sent off Nani in the second leg of the Champions League round of 16 tie with Real Madrid, a game which Sir Alex Ferguson's men went on to lose, having led at the time of the red card.
"That red card [Nani against Real Madrid] was heavily unjustified," Van Persie told reporters. "It was not even a yellow card or a free kick. Nani couldn't do anything about it, he hardly touched Arbeloa.
"The worst thing is that UEFA supports him. That's cowardly, because I really don't understand it.
"Why don't they just be honest and say: 'He hasn't seen it?'
"I didn't understand before the game that this man would be the referee, such an unknown referee who hasn't been in charge of a big game for months.
"Even the guys from Madrid told me afterwards that it was not a red card."
The Red Devils were on course for a place in the quarter-finals prior to the sending off, leading 1-0 on the night and 2-1 on aggregate; however, two goals in the space of four minutes put paid to their chances of progression, and Van Persie is adamant that it would have been a different story if they still had 11 men on the pitch.
"For an hour everything was looking good, the tactics seems to be right," van Persie said. "We really had the feeling that we were going to score the second goal and then it would become very difficult for Real Madrid. But then it the referee pulled the red card."