The side from the capital lost it matchday two fixture, a shock 2-1 defeat to Getafe, as Barcelona came from behind to beat Osasuna by the same score.
Still, Pique says that it will be a long battle to reclaim the title.
"It's surprising that Madrid has only one point right now, but they could easily go the next 30 games without a loss," Pique explained at a Barcelona press conference. "I was very motivated for this season. It couldn't have started better, but La Liga is about 38 games, not about two."
Meanwhile, Carlos Puyol is a doubt for Barca's vital Spanish Supercopa fixture against Madrid after the 34-year-old suffered a suspected fractured cheekbone in the win over Osasuna, following a collision with Roland Lamah.
"Knowing him, I wouldn't yet say he won't play on Wednesday," joked Pique, who remains optimistic about the fixture. "We want to win the Super Cup, it would be the fourth in a row. We will go to Madrid trying to win the game."
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