The international defender is surprised that the champion has yet to win this season, but has played down any suggestions that the lack of form is significant.
The side from the capital lost it matchday two fixture, a shock 2-1 defeat to Getafe, as Barcelona came from behind to beat Osasuna by the same score.
Still, Pique says that it will be a long battle to reclaim the title.
"It's surprising that Madrid has only one point right now, but they could easily go the next 30 games without a loss," Pique explained at a Barcelona press conference. "I was very motivated for this season. It couldn't have started better, but La Liga is about 38 games, not about two."
Meanwhile, Carlos Puyol is a doubt for Barca's vital Spanish Supercopa fixture against Madrid after the 34-year-old suffered a suspected fractured cheekbone in the win over Osasuna, following a collision with Roland Lamah.
"Knowing him, I wouldn't yet say he won't play on Wednesday," joked Pique, who remains optimistic about the fixture. "We want to win the Super Cup, it would be the fourth in a row. We will go to Madrid trying to win the game."
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