First-half goals from Pedro and Roberto Soldado helped Spain to a comfortable lead before Luis Suarez pegged one back in the closing stages of the game and Iniesta was pleased with his side's display in their Group B opener.
"The team put in a great performance and worked very hard. We are on the right track with two games left in the group stages," the Barcelona star told reporters. "We knew that Uruguay were going to approach the game aggressively and would not allow us time to think on the ball. We always made the right decisions, though, and always picked the right pass.
"We struggled a bit with the humidity towards the end. We were looking for a third goal, but were unable to get one. The overall feeling is good, though."
Spain takes on Tahiti on June 20 in its second group game.