Bayer travels to face Borussia Monchengladbach with hopes of strengthening its second-place position and injuries to Sami Hyypia's team mean Guardado is likely to see playing time.
Hyypia stressed in Thursday's pregame press conference that Guardado is in line for minutes, but that his adaption to Leverkusen will also take time.
"Andres looks very good on the ball and is an option for Friday," said Hyypia. "But we must give him time to get used to our system and understand what is required."
Guardado has been featuring at left back in training this week, according to various reports out of Germany, and has been garnering plenty of attention from fans wanting photos and autographs.
Mexico coach Miguel Herrera is set to meet with Guardado in the coming days about the player's role in the national team and could even be at Friday's game, as the 45-year-old continues paying visits to Mexican players based in Europe.
Leverkusen is Guardado's fourth professional team after he debuted for Atlas in Mexico and moved on to Deportivo La Coruna and then Valencia.