The Barcelona and Real Madrid stars both made the cut for the world's Best XI in 2012, alongside a host of teammates and Atletico Madrid's Radamel Falcao.
The FIFPro World XI is a prize from the players for the players, with FIFPro inviting all professional footballers in the world to compose their best team of the year.
Real Madrid goalkeeper Iker Casillas earned the nod at goalkeeper, while his teammates Sergio Ramos and Marcelo made it into the defense alongside Barcelona duo Dani Alves and Gerard Pique.
The three-man midfield consisted of Real Madrid star Xabi Alonso, partnered by his Spain teammates and Barcelona foes Xavi and Andres Iniesta.
Unsurprisingly, both Ronaldo and Messi made the cut up front, with Atletico Madrid striker Radamel Falcao completing the FIFPro World XI.
Notable snubs included Juventus' Andrea Pirlo and Manchester United's Robin van Persie.
FIFPro World XI (4-3-3): Casillas; Dani Alves, Pique, Sergio Ramos, Marcelo; Xabi Alonso, Xavi, Iniesta; Messi, Falcao, Cristiano Ronaldo