BVB has been drawn in the same group as Arsenal, Anderlecht and Galatasaray but the Germany international believes Jurgen Klopp's men can reach the knockout stage.
Friday's draw for the group stage of Europe's premier club cup competition pitted the German outfit against Arsenal, Anderlecht and Galatasaray.
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BVB faced the Gunners in last season's competition, with both sides scraping into the knockout stage at the expense of Napoli, after all three had finished with six points from six games.
Hummels believes that BVB, who finished as runners-up to Bayern Munich in 2013, have sufficient quality to make the last 16 once again this term.
"With Anderlecht and Galatsaray we have drawn new and interesting teams," the center half mused. "Arsenal, somehow, are a part of our Champions League experience.
"But we expect from ourselves to progress."
Dortmund boss Jurgen Klopp also acknowledged his side's familiarity with Arsenal but was more intrigued by the unknown quantities in Group D.
"We will meet familiar and new faces," the 47-year-old coach stated. "I have never been to Anderlecht and Istanbul before.
"We did not wish for an opponent ahead of the draw, so we will take it as it is. On Saturday, we will start collecting information about these teams, but we know Arsenal best, that is for sure."
Meanwhile, BVB midfielder Ilkay Gundogan is particularly excited about his side's home-and-away clashes with Galatasary.
"Because of my Turkish roots, matches against Turkish opponents are something special for me," the Germany international explained. "Arsenal is a top team and these matches will give us and our fans the possibility to meet some guys from the national team again. It will be emotional.
"And everybody who followed Anderlecht a little recently know, how they have great talent and quality."