The Argentine is ready to chop and change his starting XI as the race for La Liga enters the home straight.
Atletico Madrid coach Diego Simeone will look to utilize his full first-team squad in a bid to clinch the La Liga title.
Ahead of Wednesday's clash with Granada, Atletico sits level on points with Real Madrid at the top of the table and one ahead of third-placed Barcelona.
With a first title since 1996 firmly in sight, Simeone will look to rotate and rest players accordingly to deal with a run-in that also involves at least two matches in the Champions League.READ MORE: Violence raises its head in Mexico | Looking at USA squad for Mexico match
"We only aspire to be competitive in each match. At this end of the season all the players are essential. We have to look for the best alternatives to play each match, which are three days apart," he said.
"I have faith in all the guys that have trained and are waiting for their opportunity. When I deem it necessary to make them play, I won't hesitate. We need them and they have been long expecting it."
Simeone has not been afraid to experiment in attack, with David Villa and Raul Garcia having been utilized alongside or behind Diego Costa.
"With Raul, because of his nature, we have a midfielder who plays more centred and arrives better to the box," Simeone added.
"David Villa is closer to the forward figure we all know, with better results in short distances and it obviously makes us work differently."