The Belgian believes the Ligue 1 champions have a similar playing style to Arsenal and believes that they can enjoy success against Laurent Blanc's men by pressing high.
After eliminating Galatasaray in the round of 16, the Blues travel to France for their first leg next Wednesday, before hosting the Ligue 1 champions in the return fixture on April 8.
Hazard, who has scored 16 goals in all competitions this season, also feels PSG's playing style is similar to that of Premier League rivals Arsenal - whom the Blues routed 6-0 on Saturday.
"I think the coach is strong enough to handle these kind of matches. We must be strong defensively," the Belgian told Canal+. "We know Paris like to play as Arsenal: Paris play good football; Paris dominate their matches. But if we press them..."
When it came to naming PSG's best player, Hazard argued that while there is one obvious answer to that question, Laurent Blanc's side is packed with world-class talent.
"Who impresses me the most? Ibra [Zlatan Ibrahimovic], of course," the winger said. "But Thiago Motta is also a great player. Yohan [Cabaye] is part of the great players, [Edinson] Cavani also, and their defense is tough."