The Belgian outfit suffered a last-gasp defeat on Wednesday to bring its Champions League campaign to an end and their coach admitted minor mistakes had cost it this season.
The loss ended Anderlecht's chances of reaching the Champions League's round of 16, with the Belgian outfit now having won just a solitary point from five Group C matches.
Chancel Mbemba Mangulu had given Anderlecht the lead, but goals from Nemanja Matic and Nicolas Gaitan fired Benfica in front.
And although Massimo Bruno levelled proceedings with 14 minutes left, Rodrigo struck a late winner for Benfica.
Van den Brom could not fault the efforts of his players, though, and refused to blame them afterwards, although he did concede it was the "minor details" of matches which had ultimately condemned his side to an early exit.
"We played to win. Until the last moment we really gave everything, but nothing fell in place. We continue with empty hands, which is disappointing," he said. "The pace of the match was at a gigantic high. It was constantly up and down. This requires a huge amount of players.
"The victory was in sight. We go out by small details. At this level, every mistake is punished."