Arsenal, Schalke, Atletico Madrid and Barcelona all recorded their second wins of the campaign on Tuesday night, but in Wednesday's Big Match, will it be Manchester City or Bayern Munich securing maximum points?
In the week's second instalment of Champions Club, Nat Coombs is once again joined by Champions League winner Andrew Cole, and International Football Writer Peter Staunton to preview all of today’s action.
In Tuesday's show, Cole backed Mesut Ozil to be his star player, and the German did not disappoint, scoring his first goal for the club - and supplying yet another assist - in Arsenal's 2-0 victory over Rafa Benitez's Napoli.
Meanwhile, Manchester United will be looking to put its lackluster start to the Premier League season firmly behind it in Donetsk, as David Moyes' side takes on Shaktar. Check out the video to see what the guys predict for this, and the other seven of today's matches.
To have your say, remember to tweet us using the hashtag #ChampionsClub to predict your winners and star players for today's games, and stay tuned to Goal for all the action with our Live Match Centre!