The 53-year-old thinks the time has come for German football to replace the Spanish game as the dominant force.
Bayern recorded a 4-0 win over Barca at the Allianz Arena last week, while BVB defeated Madrid 4-1 at the Signal Iduna Park, and Schuster feels it might be Germany's turn to become the dominant force.
"Football works in generations," the former West Germany international told Marca. "Over recent years Spain has had a great team and has produced some fantastic players, but every cycle comes to an end, much like what happened with Italy or Brazil.
"German football is trying to climb to the top of the pile right now. The first legs produced surprising results, but you have to believe it's possible to turn the ties around."
Madrid hosts Dortmund on Tuesday as it attempts to overturn a 4-1 first-leg loss, while Barcelona takes on Bayern at Camp Nou on Wednesday.