The Blaugrana were paired with Bayern Munich during Friday's semifinal draw, while the capital club will have to deal with Borussia Dortmund if it is to make it to the showpiece at Wembley.
And the former Blancos boss feels a matchup between the two Spanish giants would be ideal.
"Everybody wants a final between Barcelona and Real Madrid," Del Bosque told reporters. "It would be a great final if Barca and Madrid were to meet as the majority of the players also play for Spain's national team. It would be another huge step for Spanish football.
"Over the past decade or so we have seen a Spanish hegemony with teams like Valencia, Sevilla, Villarreal and Deportivo doing well, too."
Spanish teams have won five out of the 13 Champions League finals since the beginning of the millennium.