The former Blaugrana striker believes having the second leg in Spain will be tough for the Ligue 1 leader, with the size and quality of Barcelona's pitch a key factor.
In an exclusive interview with Goal.com, Kluivert insists with talisman Zlatan Ibrahimovic suspended for the first leg, and the second leg being played at Camp Nou, both factors will make it harder for the Ligue 1 side to progress.
"It's going to be very difficult. Without Zlatan Ibrahimovic in the first game in their own stadium will be difficult, but the most important thing is that they play the second game in Barcelona, playing on a pitch which is 105 metres by 68 metres," Kuivert said. "It's very difficult to defend on that, because if you defend in the midfield you give them more space between the lines. If you defend outside, you leave space inside, so it will be very difficult to work out how they can beat Barcelona."
The 36-year-old Kluivert believes the difference in pitch size between Camp Nou and San Siro was also a key factor in the differing results in Barcelona's last-16 tie with Milan.
"The pitch at San Siro is a lot smaller, and that wasn't good for playing their possession game. But at Camp Nou they cut the grass with scissors, it's like a snooker table, and that's what's right for their possession game. If they are feeling good and their players are ready, you will have difficulties."
Kluivert was in Nyon to make the draw for the quarterfinals of the Europa League, and he believes an all-English final in that competition is a distinct possibility. Tottenham, Chelsea and Newcastle are still alive and will play FC Basel, Rubin Kazan and Benfica, respectively.
"It's very possible, because if I had drawn two English teams then one English team was already out, so it's very possible that we could have an English final," Kluivert said.