The Norwegian believes that the Champions League tie between the two European giants will be very tight and could be decided by a moment of magic from either attacker.
The Dutchman moved to Old Trafford from Arsenal in the summer, and has led his new side's title charge, while the Portuguese has been in fine form of late, scoring a hat trick against Sevilla on Saturday.
Solskjaer believes that the result may well come down to which of the two players is on form on the night.
"Both coaches know each other well and the teams are very evenly matched. I think it will be decided by a moment of genius from Van Persie or Ronaldo," he told Marca. "I want Manchester United to win, but, for the first time, I really don't know what's going to happen. I'd like a 4-3, with Cristiano scoring three goals.
"Almost everything I know, I've learned from Sir Alex. We both believe in ourselves, we always want to win, we invest in young people and work hard. The bigger the challenge, the more Ferguson gets out of it."