The Camp Nou club has secured nine points in three matches and a win on Wednesday night would see the Blaugrana qualify for the knockout stage with two games left to play.
The Catalunya club has claimed nine points from its first three matches, and a win in Glasgow would see the Spanish power qualify for the knockout stage with two games remaining. Pep Guardiola's successor has admitted that the Scottish club will put up an almighty fight on Wednesday night, with Barcelona needing a late goal to ensure victory in the 2-1 Camp Nou result last month.
"The match against Celtic is possibly the most important match we have left in 2012. If we win we'll be in the next round," Vilanova told reporters on Tuesday. "We know how dangerous Celtic are. We need to be wary of their set-pieces and their counterattacks. The players are aware of how difficult tomorrow's match will be."
The Blaugrana coach also confirmed that Gerard Pique could return to defense, but that he will make a decision after Tuesday's training session.
"The sooner we can get players like Gerard Pique and Carles Puyol back, the better," Vilanova said.