Catalan coach Pep Guardiola names an attacking lineup for the Camp Nou clash, with Alexis Sanchez and Cesc Fabregas both included against the Blues, who lead the tie 1-0
Dani Alves surprisingly misses out as Gerard Pique is restored in a three-man back line, while Isaac Cuenca starts alongside Lionel Messi and Alexis Sanchez in attack.
Cesc Fabregas, Xavi, Andres Iniesta and Sergio Busquets are named by coach Pep Guardiola in a formidable midfield four, while Javier Mascherano again starts in defence.
Chelsea, meanwhile, is unchanged from the first leg as Didier Drogba is once again preferred to Fernando Torres.
Drogba's goal at Stamford Bridge last Wednesday separates the two teams ahead of this match.
Barcelona (3-4-3): Valdes; Pique, Mascherano, Puyol; Busquets, Fabregas, Xavi, Iniesta; Alexis, Messi, Cuenca
Subs: Pinto, Dani Alves, Thiago, Adriano, Keita, Pedro, Tello
Chelsea (4-3-3): Cech; Ivanovic, Cahill, Terry, Cole; Meireles, Mikel, Lampard; Ramires, Drogba, Mata
Subs: Turnbull, Bosingwa, Essien, Malouda, Kalou, Sturridge, Torres
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