The defensive midfielder acknowledged that the Blues, with the help of the home crowd, will not make it easy for Guardiola's men in Wednesday's clash, but added that the Blaugrana are keen to get a result in the first leg.
"Our challenge is to keep to our style and system and forget the atmosphere. We want to score goals, as it makes it easier to cope with the second leg," Busquets said to The Daily Mirror.
"Chelsea are a big club and the semifinal will be very even. No team is ever such a clear favorite at this stage of competition. People may see us as favorites, but we must remain focused if we are to reach the final."
The Spain international then went on to praise teammate Lionel Messi, and reiterated that the Argentine is the best player in the game today.
"Messi is the number one player in the world. That is not open to question. He provokes fear in opponents and that also helps his team-mates. It's a big advantage for us.