Pep Guardiola recalls the two midfielders, but is without both Xavi and Pique for the last-16 clash in Germany
All three midfielders were left on the bench as a weakened Barca team lost 3-2 to Osasuna in La Liga on Saturday, but Xavi is still feeling the effects of an injury and misses out altogether.
Gerard Pique is also out as Javier Mascherano starts in defense, but Sergio Busquets is back in midfield.
Leverkusen, meanwhile, starts with no recognized striker as Andre Schurrle leads the line for the Bundesliga outfit.
Leverkusen (4-3-2-1): Leno; Corluka, Schwaab, Friedrich, Kadlec; Rolfes, Reinartz, Bender; Renato Augusto, Castro; Schurrle
Barcelona (4-3-3): Valdes, Alves, Puyol, Mascherano, Abidal; Fabregas, Iniesta, Busquets; Adriano, Messi, Alexis