The old boys are back in town in the first of the mouth-watering ties between Europe's finest. Goal.com looks ahead to the contests and picks out a few bets to wager on.
Lyon - Real Madrid
To Win Champions League: Lyon 50/1, Real Madrid 5/1
Recent Form: (2006/07) Lyon 2-0 Real, Real 2-2 Lyon, (2005/06) Lyon 3-0 Real, Real 1-1 Lyon
Los Blancos might just give themselves a nosebleed if they progress from this match-up. Since the last 16 knockout was introduced in the 2003-04 season Real have been eliminated at the first time of asking every time except once when in 2004 they were dumped out by Monaco at the quarter-final stage.
Lyon Win: 23/10, Real Win: 11/10, Draw: 9/4
Real to win both legs: 7/4, Lost both legs: 20/1
Lyon to win both legs: 20/1, Lose both legs: 7/4
Real to reach quarter finals at exit at that stage: 3/1
Now they face another French club who boast an unbeaten record against the Spanish giants in the Champions League. Lyon are seeking a hat-trick of home victories having thumped Real 3-0 in 2005 and 2-0 at the Stade Gerland a year later, both times in the group stage. They nearly completed the double in '06 at the Bernabeu when goals from Ruud van Nistelrooy and Lyon old boy Mahamadou Diarra rescued a point for the Whites.
Injury is likely to prevent us from seeing Karim Benzema in action against his former side after the Real striker picked up a knock. The summer signing's absence may give Raul the opportunity to add to his 66 Champions League goals and given the rumours linking the hitman with a move to the MLS it could well be the last we see of him in Europe's premier competition.
Karim Benzema to score at any time: 6/4, Ronaldo 5/4, Raul 7/4, Kaka 11/4, M. Diarra 13/2
Lisandro Lopez to score at any time: 9/4, Gomis 12/5, Cris 11/4, Makoun 4/1
With this year's final being held at the Santiago Bernabeu, the expensively assembled new Galacticos simply must progress beyond the last 16. They've already won in France this season, beating Marseille in the group stage, and are meeting a Lyon side who are not the force they were, particularly in Europe, where they have gone out in the last 16 for the past three seasons.
A good omen for Manuel Pellegrini is that Manchester United and Barcelona, who knocked out Lyon in 2008 and 2009, both went on to win the competition.
Real to reach final at Bernabeu: 13/8, Lyon 25/1
Real to reach final and win: 5/1, lose final 11/2
Lyon to reach final and win: 50/1, lose final 33/1
Milan - Manchester United
Recent Form: (2006/07) Milan 3-0 Man Utd, Man Utd 3-2 Milan, (2004/05) Milan 1-0 Man Utd, Man Utd 0-1 Milan
To Win Champions League: Milan 20/1, Manchester United 8/1
Ten European Cups between them with at least one of these giants featuring in four of the last five finals. Boot in a David Beckham reunion (watch out Fergie) and we have a mouth-watering occasion at the San Siro to savour.
Neither though are among the favourites to go all the way this season with the Premier League champions priced at 8/1 while Milan are a tasty 20/1. It's arguable who has suffered more from the loss of their respective talismen, Ronaldo and Kaka, but both have coped in their absence to reach the knockout stages once again.
Milan win: 13/8, Man Utd win 17/10, Draw 2/1
Milan to win both legs: 8/1, lose both legs 4/1
Man Utd to win both legs: 4/1, lose both legs 8/1
Man Utd not to lose in Milan but get beaten at home: 11/2
It's the third Anglo-Italian clash to feature these sides in recent season. United were beaten in the last 16, 1-0 home and away, by the Rossoneri in 2005 and a Kaka-inspired performance two years later put paid to their dreams at the semi-final stage. Since that 3-0 hiding on a rainy Milanese night the Red Devils haven't lost away from home in Europe in 15 matches, eliminating Roma and Inter along the way.
Milan have never lost over two legs against their English visitors. Indeed, United have yet to score a goal in the San Siro against the Serie A side. Glance through the history books and the scoreline in Italy reads Milan 10-0 Manchester United. The Rossoneri beat a makeshift United side 4-0 at the semi-final stage in 1958 after the Munich air disaster and 11 years later, also in the semis, they won 2-0 to knock the then holders out.
David Beckham to score at any time: 7/2, Inzaghi 7/4, Ronaldinho 7/4, Borriello 7/4, Pato 6/4
Wayne Rooney to score at any time: 6/4, Berbatov 9/4, Valencia 7/2, Scholes 4/1
Predictably, the headlines are all about David Beckham. Milan's number 32 won the Champions League with United in 1999 and has scored 17 goals in the competition in his 109 appearances. Hmm, I wonder who is going to tell Ronaldinho he's not taking the free-kicks in this one...
David Beckham to score a free-kick: 22/1, score the winner 33/1, sent off: 20/1
Milan to reach final: 9/1, Man Utd 7/2
Milan to reach final and lose: 16/1, Man Utd 7/1
A comprehensive list of bets for the Champions League can be found on the Titanbet website.
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