The former Fiorentina trainer refused to be downbeat about the loss to the North Americans and believes his side will still have a positive showing at this summer's tournament.
Italy fell in Genoa to a solitary strike from Clint Dempsey that saw the home side lose its first-ever match to the USA in an 82-year history between the teams.
Speaking to reporters immediately following the loss, Prandelli proclaimed his optimism as Italy approaches Euro 2012 in June.
"It was an undeserved loss, but with this spirit we will have a great European Championship because I was happy with the squad," he said. "Obviously to play every three months is complicated, but I'm convinced that we will have a great Euro 2012."
The 54-year-old then commented on some of the individual performances, including starter Sebastian Giovinco and debutant Fabio Borini.
"Giovinco? He did good things and was dangerous one-on-one. Borini has determination, personality and alot more," he said, singling out the two forwards for praise.
Finally, when asked if he was concerned about the loss given how close the Euro 2012 is, Prandelli shrugged off the defeat.
"One-hundred days from the Euros? I am absolutely not worried," he said.
Italy takes on the reigning European champion Spain in its opening match on June 10.