The former FC Dallas winger came on in the 24th minute and made an impact on the match playing on the left wing.
The American international made Stoke City's bench for the first time since his transfer last month, and he was thrust into action in the 24th minute against Fulham after Matthew Etherington went down with a back injury.
Shea was understandably a bit rusty as he took the pitch in what was his first match in several months. The former FC Dallas midfielder missed the end of the MLS season and U.S. national team duty with an abdominal strain stemming from a foot injury.
The 22-year-old grew into the match though, and 10 minutes after the break, he won his side a penalty kick when his pass struck Ashkan Dejagah's arm in the box. However, Jon Walters had his spot kick saved by Mark Schwarzer, as Fulham won 1-0 on the strength of a Dimitar Berbatov strike.
Shea could make his first EPL start in Stoke City's next match, a home date with West Ham on March 2.